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PNC 27 10mg*10vials
PNC 27 10mg*10vials $209.00
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PNC 27 5mg*10vials

$132.00

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描述

1. Core Identity & Mechanism

PNC 27 is a synthetic cationic peptide derived from the p53 tumor suppressor protein (specifically the α-helical domain of p53). Its primary mechanism targets abnormal cell membranes (e.g., cancer cells, pathogenic microbes) while sparing healthy cells, making it a valuable tool for targeted therapy research.
Key mechanisms:
  • Cancer Cell Selectivity: Binds to the overexpressed oncoprotein MDM2 (a negative regulator of p53) on cancer cell membranes, forming pores that disrupt membrane integrity and induce cancer cell apoptosis (programmed cell death).
  • Antimicrobial Activity: Interacts with the negatively charged membranes of bacteria/fungi, causing membrane permeabilization and microbial lysis (effective against both Gram-positive and Gram-negative bacteria, as well as drug-resistant strains).
  • Low Off-Target Effects: Healthy cells with normal p53/MDM2 expression are unaffected, as PNC 27’s binding affinity for MDM2 is significantly higher in cancerous cells.

2. Primary Research & Functional Benefits

  • Anticancer Research (Core Application)

    PNC 27 is widely used in preclinical oncology research for:

    • Targeted apoptosis induction: Effective against a broad range of cancer cell lines (e.g., breast, lung, colon, melanoma, leukemia) by exploiting MDM2 overexpression—ideal for studying p53-MDM2 pathway targeting.
    • Drug resistance reversal: Shows potential in overcoming chemotherapy resistance (e.g., cisplatin, doxorubicin) by directly targeting cancer cell membranes, independent of traditional apoptotic pathways.
    • Combination therapy studies: Enhances the efficacy of existing anticancer drugs when co-administered, reducing required doses and minimizing systemic toxicity.
    • Tumor xenograft models: Used to evaluate in vivo anticancer activity, tumor growth inhibition, and safety profiles in animal models.

  • Antimicrobial Research

    In infectious disease research, PNC 27 exhibits value for:

    • Fighting drug-resistant pathogens: Active against MRSA (Methicillin-resistant Staphylococcus aureus), Pseudomonas aeruginosa, and Candida albicans—relevant for antibiotic resistance research.
    • Broad-spectrum activity: Targets both bacteria and fungi by membrane disruption, avoiding the development of resistance associated with conventional antimicrobials.

  • Biomedical & Therapeutic Development

    Preliminary research indicates potential for:

    • Topical therapy development: Suitable for formulating wound dressings or creams to treat infected wounds (combines antimicrobial and anti-inflammatory effects).
    • Anticancer drug delivery: Can be conjugated with nanoparticles or targeting ligands to enhance tumor penetration and reduce systemic side effects (studied in targeted drug delivery systems).
After-sales guarantee
The company assigns a 1-on-1 service specialist to each customer, providing professional technical consultation and answering questions related to product application. The products are also provided with authoritative COA test reports, clearly indicating a purity of ≥ 99%, meeting the quality verification and traceability needs of various customers. Relying on compliant qualifications and a mature logistics system, there is no customs clearance risk. After the order is confirmed, the products will be shipped within 48 hours. Whether it is a small purchase or a bulk order, the delivery time can be guaranteed. The company establishes an exclusive customer service file, regularly following up on usage feedback and replenishment needs. In case of quality issues not caused by human factors, the company supports return and exchange services, and also provides a rapid replenishment solution. With a high repurchase rate and excellent reputation, it ensures the entire process of cooperation for every customer.